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Specific Cancers: Anal Cancer
Deciding on Treatment

What to Know About Chemotherapy for Anal Cancer

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Chemotherapy drugs kill all cells that grow rapidly, including cancer cells.

Chemotherapy is the use of drugs to kill cancer cells. For this treatment, you see a medical oncologist. This is a doctor who specializes in using drugs to treat cancer. For anal cancer, your doctor is likely to give you more than one drug. This is called combination chemotherapy.

You may take these drugs by an intravenous (IV) into a vein or in a pill. Either way, chemotherapy is a systemic treatment because the drugs travel all through the body in your bloodstream. Most people with anal cancer have chemotherapy in an outpatient part of the hospital, at the doctor’s office, or at home. In some cases, depending on your health or the drugs you take, you may need to stay in the hospital during treatment.

Chemotherapy is given in cycles. This means you are treated for a period of time with chemotherapy and then you have a rest period. Each treatment and rest period make up one cycle. You’ll likely have more than one cycle of treatment. Your doctor will explain what your treatment plan will be and what you can expect. The length of each treatment period differs depending on the type of drug you take. With many types of chemotherapy, monthly treatments are common. Sometimes you will get chemotherapy more often.

Common Chemotherapy Drug Combinations

These are the main chemotherapy regimens doctors use to treat anal cancer.

  • 5-FU (5-fluorouracil) and Mutamycin (mitomycin C)

  • 5-FU and Platinol-AQ (cisplatin) 

Doctors often give chemotherapy in combination with radiation therapy. This is called chemoradiation.

For some people, anal cancer comes back. This can happen even when treatment with chemotherapy and radiation is effective. If the cancer is growing near the anus, the doctor may recommend surgery or more radiation. If the cancer has spread away from the anus, the doctor may recommend more chemotherapy.

Online Medical Reviewer: Berg, Deborah RN, BSN
Online Medical Reviewer: Copur, Mehmet Sitki MD, FACP
Date Last Reviewed: 11/13/2005
Date Last Modified: 3/29/2006
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